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Who should not take buprenorphine HCl and naloxone HCl?

You should not take buprenorphine HCl and naloxone HCl if you are using:

  • antifungals, such as ketoconazole; macrolide antibiotics, such as erythromycin; 
  • and HIV protease inhibitors, such as ritonavir; benzodiazepines, such as diazepam; 
  • narcotic pain medication; cimetidine; phenothiazines, such as chlorpromazine; 
  • sodium oxybate (GHB); naltrexone; rifampin; and methadone.

Additionally, you should not take buprenorphine HCl and naloxone HCl if you are pregnant, planning on becoming pregnant, or breast-feeding. If you have had a head injury; increased brain pressure; growths in your brain; problems with your blood, muscles, lungs, thyroid, adrenal glands, kidney, liver, gallbladder, or stomach; an enlarged prostate; blockage of your urethra or bladder; or trouble urinating, you should speak to your doctor prior to taking buprenorphine HCl and naloxone HCl.

You should also tell your doctor if you have ever had an allergic reaction to buprenorphine, naloxone, other medications, or any types of foods. People with a history of mental illnesses, mood problems, and drug or alcohol abuse should not use buprenorphine HCl and naloxone HCl without a thorough discussion with the doctor of the risks and benefits.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.