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Can varenicline cause changes in mood?

The Food and Drug Administration (FDA) requires that varenicline (Chantix) carry a warning because mood changes may occur in people taking varenicline for smoking cessation. The warning lists the following as possible mental health problems associated with varenicline:
  • Extreme neuropsychiatric problems such as depression, suicidal thoughts and attempted suicide.
  • Exacerbation of underlying mental health illnesses.
  • Neuropsychiatric symptoms, including mood swings, psychosis and hostility.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.