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Can naltrexone effectively treat opioid addiction?

Howard J. Shaffer, PhD
Addiction Medicine
Although the Food and Drug Administration-approved, for use with people struggling with opioid addiction, naltrexone (Depade, ReVia, Vivitrol), it does not have a good track record of helping people stay opioid-free. The reason might be because naltrexone triggers withdrawal, so people often are unwilling to take it as directed. Long-acting naltrexone (Vivitrol), which is given by injection at the doctor's office and lasts for a month, might prove better at keeping people off opioids, but one review article concluded that there is not enough evidence to make that claim.

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