Advertisement

Do buprenorphine HCl and naloxone HCl interact with other drugs or food?

Buprenorphine HCl and naloxone HCl can interact with a number of types of medications. The side effects of buprenorphine HCl and naloxone HCl can be increased when also taking:

  • azole antifungals, such as ketoconazole; macrolide antibiotics, such as erythromycin; 
  • and HIV protease inhibitors, such as ritonavir. 

The risk of seizures is increased when you are also taking benzodiazepines, such as diazepam; narcotic pain medication, such as codeine; cimetidine; phenothiazines, such as chlorpromazine; or sodium oxybate (GHB).The effectiveness of buprenorphine HCl and naloxone HCl is decreased by naltrexone and rifampin, and buprenorphine HCl and naloxone HCl decreases the effectiveness of methadone.

Tell your doctor about any medications you are taking in order to assess whether or not you will have a serious drug reaction when you take buprenorphine HCl and naloxone HCl. This drug should not be taken with alcohol, as it may increase side effects.

Continue Learning about Dependency Agent

What should I know before taking varenicline?
Donna Hill Howes, RNDonna Hill Howes, RN
Bupropion and varenicline have been shown to help people with schizophrenia quit smoking. But relaps...
More Answers
How effective is varenicline?
Donna Hill Howes, RNDonna Hill Howes, RN
Studies show that people who use varenicline at the recommended dose of 2 mg a day are 3 times more ...
More Answers
What are the side effects of varenicline?
Dr. Frank T. Leone, MDDr. Frank T. Leone, MD
Varenicline can be used to help you stop smoking, as it reduces the urge to smoke. However, it may c...
More Answers
What drugs may interact with varenicline?
Donna Hill Howes, RNDonna Hill Howes, RN
Some patients who took varenicline along with nicotine replacement therapy (NRT) reported higher rat...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.