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Lycopene may interact with certain medications used to treat cancer and bacterial infections. The safety of lycopene supplements has not been thoroughly studied. Review of available scientific literature finds tomatoes, tomato-based products and lycopene supplements generally well tolerated. However, rare reports of diarrhea, nausea, stomach pain or cramps, gas, vomiting and loss of appetite have been reported. Tomatoes and tomato-based products may be acidic and irritate stomach ulcers. Lycopene has been associated with death from a cancer-related hemorrhage, although causality is unclear.
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