Q

Liver Disease

What are the causes of cirrhosis?

A Answers (4)

  • Cirrhosis of the liver is the end result of chronic injury to the liver from various causes. They include:Alcoholic Liver DiseaseInfectionChronic Hepatitis B virus infection (with delta hepatitis in some cases)Chronic Hepatitis C virus infectionAutoimmune diseasesAutoimmune hepatitis (AIH)Metabolic diseasesHemochromatosis which is an iron metabolism abnormality leading to iron deposition within the liver.Wilson’s Disease which is a copper metabolism abnormality leading to copper deposition within the liver (Can also present as acute liver failure) Cholestatic Liver DiseasePrimary biliary cirrhosis (PBC) Primary sclerosing cholangitis (PSC)  Secondary biliary cirrhosis (extrahepatic biliary obstruction)Biliary atresia (in children)Non-Alcoholic Fatty Liver Disease (NAFLD) / Non-Alcoholic Steohepatitis (NASH)Drugs  (i.e. Methotrexate and Amiodarone)Vascular disease of the liver (i.e. Budd-Chiari Syndrome)Cryptogenic Cirrhosis (unidentifiable cause but may include several cases of NAFLD)Miscellaneous causesAlpha 1 antitrypsin deficiencyGlycogen Storage DiseasesSevere heart failure with congestion of the liverParasitic infestation like schistosomiasis
  • Cirrhosis, scarring of the liver caused by injury over a period of time, is a consequence of chronic hepatitis (viral hepatitis that is not cleared from the body by the immune system), excessive alcohol use, and other less common causes including infections, drug toxins, and inherited diseases.
  • Cirrhosis has various causes. In the United States, heavy alcohol consumption and chronic hepatitis C have been the most common causes of cirrhosis. Obesity is becoming a common cause of cirrhosis, either as the sole cause or in combination with alcohol, hepatitis C, or both. Many people with cirrhosis have more than one cause of liver damage.

    Cirrhosis is not caused by trauma to the liver or other acute, or short-term, causes of damage. Usually, years of chronic injury are required to cause cirrhosis.

    This answer is based on source information from the National Institute of Diabetes and Digestive and Kidney Diseases.

  • There are many causes of cirrhosis of the liver, including:
    • drinking alcohol heavily during one's life
    • hepatitis virus
    • nonalcoholic fatty liver disease, a condition of the liver
This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.
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