What other than prostate cancer can produce an elevated PSA level?

The most common cause of an elevated prostate-specific antigen (PSA) is an enlarged prostate that occurs in most men as they age. This has prompted some prostate cancer experts to recommend using higher PSA thresholds for abnormal with increasing age. An inflammation of the prostate, called prostatitis, can also cause a borderline high PSA level.

Several other conditions can cause a temporary increase in PSA. These include urinary retention, or having a prostate biopsy, a cystoscopy procedure, or a urethral catheterization. Having a digital rectal exam or sexual activity with ejaculation cause minor elevations of PSA. Some doctors suggest that men abstain from sexual activity for two days before having the test.


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