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Can bedwetting be treated with medication?

Stacy Wiegman, PharmD
Pharmacy Specialist

The antidepressant Tofranil (imipramine) can be prescribed for children ages 6 and older to help prevent bedwetting, although doctors don’t have a clear understanding of how it works. It’s typically given one to two hours before bedtime, but kids who tend to wet the bed early in the night may take one dose in the afternoon and another before going to sleep.

As with other bedwetting medications, once a child stops taking Tofranil he may well begin wetting the bed again.

Bedwetting can be treated with medication. These medications work either by reducing the amount of urine people make during the night, or by stopping the bladder from emptying when it shouldn’t. Medicines are taken one to two hours before going to bed. It’s important to only have a few sips of water after taking the medicines. Some of the medicines do not need to be taken with any water at all. The medicines can help people get dry quickly, but sometimes bedwetting comes back, especially if people stop taking their medicine too soon. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.