Why do some drugs cause injury to the kidneys?

Your kidneys work with the liver to remove drugs and toxins from the body. Too much of a drug can tire out and damage the kidneys. In addition, there are some drugs that directly attack the kidneys, especially if taken in high doses.
Both prescription and over-the-counter medications are filtered by the kidneys. This means that your kidneys process and remove medications from the body. When the kidneys are healthy and you are taking medications as prescribed and according to over-the-counter instructions, the kidneys can usually properly filter these substances from the body. When your kidneys aren't working properly, medications can build up and cause you harm. It's important to get your kidneys checked and to work with your doctor to make any adjustments to your medication regimen, such as dosing changes or substitutions. This will help prevent any negative effects from the medication, including further kidney damage. If you have decreased kidney function some over-the-counter and prescription pain medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), are not recommended because they can reduce blood flow to the kidneys. Certain narcotic pain medications can build up in the body and cause serious problems for patients with chronic kidney disease. Illegal substances can also damage the kidneys.

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