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What is a sign that shows that the kidneys are not working well?

Metformin is excreted primarily through your kidneys. When your kidneys are not working well, metformin can build up in your body and cause a condition called lactic acidosis. Lactic acidosis is a build up of acid in the body which can be life threatening. The drug package insert contains a \black box\" warning that states it should not be used by patients with renal dysfunction (kidney disease) and those who are taking medications for congestive heart failure (CHF).  Metformin is safe in most patients and works well in those with type 2 diabetes that are not well controlled by diet and exercise. For patients who have normal kidney and heart function.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.