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What drugs interact with eszopicline (Lunesta)?

Donna Hill Howes, RN
Family Practitioner

If you are using azelastine nasal spray, conivaptan, idelalisib, orphenadrine, paraldehyde, sodium oxybate, or thalidomide, eszopiclone can lead to side effects and should be avoided.

If you are taking a central nervous system depressant, rufinamide, or a selective serotonin reuptake inhibitor, eszopiclone may not be a good option for you.

If you take eszopiclone, you should avoid kava kava.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.