Intrauterine insemination (IUI) is performed at different stages in a woman's cycle, depending on whether or not her ovulation is being stimulated with medications.
- Without Stimulation. If no female factors are causing infertility, IUI may be performed during a natural ovulation cycle with no medications. The timing of IUI is determined by using an “ovulation predictor” urine test, with the procedure performed the day after a positive test. Ultrasound exams may be used to help determine exact timing.
- With Stimulation. To improve the chances of ovulation and to increase the number of eggs that are released, some women take medication such as clomiphene citrate (Clomid, Serophene) or letrozole (Femara). These medications are usually taken daily during cycle days five through nine, followed by IUI timed with urine luteinizing hormone (LH) kits.