Infectious Disease

What was the worst pandemic in history?

A Answers (1)

  • There are two prime contenders for the title of the worst pandemic in human history - The bubonic plague of 14th Century Europe and the Spanish flu pandemic of 1918. The Spanish flu pandemic is estimated to have affected roughly 500 million people and caused 20 million to 50 million deaths worldwide between 1918 and 1920--more than World War I. The bubonic plague killed as many as 50 million people, possibly 60 percent of the population of Europe, beginning about 1346.

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