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How do tumor necrosis factor (TNF) inhibitors treat psoriasis?

Donna Hill Howes, RN
Family Practitioner

TNF inhibitors are drugs that stop immune system cells from causing skin inflammation. They do this by blocking the action of a substance called tumor necrosis factor (TNF). TNF inhibitors approved for plaque psoriasis include adalimumab (Humira), etanercept (Enbrel), and infliximab (Remicade, Inflectra). These drugs are for people with severe psoriasis and those who do not get relief with other treatments. TNF inhibitors are given by injection.

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