What is human normal immunoglobulin?

Stacy Wiegman, PharmD
Pharmacy Specialist
Human normal immunoglobulin (HNIG) is another name for immune globulin or immunoglobulin. It is a substance obtained from the blood of human donors. Human normal immunoglobulin is marketed under a variety of brand names. It is available for intramuscular injection (IGIM), subcutaneous injection (SCIG) and, more commonly, intravenous injection (IVIG or IGIV). It contains general antibodies that are not specific to a particular infection. It is administered to people with weakened immune systems caused by primary immunodeficiency (PI), idiopathic thrombocytopenic purpura (ITP) and chronic inflammatory demyelinating polyneuropathy (CIDP). It is not intended for use in patients with acquired immune deficiencies.

Human immunoglobulin is used to treat primary immunodeficiency (PID). This treatment contains the antibiodies that might be missing in people with PID. People get the treatment as an injection under the skin at home, or through a tube that goes straight into the bloodstream at the hospital. People with PID have this treatment every one to three weeks.

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