What is the prognosis for neurological sequelae of lupus?

the newly adopted nomenclature system recognizes 19 neuropsychiatric syndromes that can be associated with systemic lupus erythematosus. These range from diffuse CNS disorders (acute confusional state or delirium, psychosis, anxiety and depressive disorders, and clinical or subclinical cognitive abnormalities of variable functional significance), to focal CNS syndromes (seizures, cerebrovascular disease, chorea and myelopathy), and peripheral nervous system disorders (polyneuropathy, mononeuropathy, plexopathy, acute inflammatory demyelinating polyradiculoneuropathy, and autonomic disorder). It is worth noting that the term “lupus cerebritis” does not appear among these 19 NPSLE syndromes.

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The prognosis for lupus varies widely depending on the organs involved and the intensity of the inflammatory reaction. The course of lupus is commonly chronic and relapsing, often with long periods of remission. Most individuals with lupus do not develop serious health problems and have a normal lifespan with periodic doctor visits and treatments with various drugs.
This answer is based on source information from the National Institute of Neurological Disorders and Stroke.

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