To diagnose mixed connective tissue disease (MCTD), doctors are looking for the overlap of symptoms from several other diseases including lupus, polymyositis, systemic sclerosis, or rheumatoid arthritis. Sometimes at first symptoms of only one of these is present - such as lupus - and thus a person will be given a lupus diagnosis. As other symptoms develop over the years, the person may then be diagnosed with MCTD. If MCTD is suspected, a blood test can be done in which the doctor is looking for an antibody called U1-RNP to confirm the diagnosis.
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