How does granulomatosis with polyangiitis affect the body?

Sigma Nursing

Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, causes immune cells responsible for inflammation to cluster together and form granulomas. These granulomas will eventually destroy the normal tissue found around blood vessels. When normal tissue is destroyed, blood flow is restricted to certain organs, causing severe damage. In fatal cases of GPA, kidney failure is the most common cause of death.

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Immune & Lymphatic System Disorders

The lymphatic system is a key part of the immune system, draining excess fluid from bodily tissues and organs and disseminating white blood cells to fight infection. The white blood cells fight infection in the spleen and special vessels throughout the body called lymph nodes. If your immune system becomes compromised, the lymphatic system wont be able to work properly, causing swelling from a buildup of fluid in parts of the body. Disorders of the lymphatic system include elephantiasis, a swelling of body parts caused by a filarial worm infestation, and lymphedema, a swelling in the arms or legs caused by lymph nodes or lymph vessels disturbed by surgery for breast or prostate cancer. Medication, massage therapy and compression garments can help.

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