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What are PCSK9 inhibitors?

Donna Hill Howes, RN
Family Practitioner

PCSK9 (Proprotein Convertase Subtilisin Kexin 9) inhibitors help the liver clear LDL cholesterol from the bloodstream. There are 2 PCSK9 inhibitors available in the US: alirocumab (Praluent) and evolocumab (Repatha). The FDA has approved them for people with cardiovascular disease or with familial hypercholesterolemia (an inherited form of high cholesterol) who haven't lowered LDL enough with statins. Alirocumab and evolocumab are taken by injection once every 2 weeks. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor. 

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.