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What is mipomersen?

Donna Hill Howes, RN
Family Practitioner

Mipomersen (Kynamro) is approved by the FDA for lowering total and LDL cholesterol in people with homozygous familial hypercholesterolemia (HoFH). HoFH is an inherited condition in which cholesterol levels are extremely high, often even with aggressive treatment with statins. Mipomersen works by limiting the production of apo-B, which is needed to build LDL cholesterol inside cells of the body. The effects of mipomersen on cardiovascular disease are not known. Mipomersen is taken once a week by injection. 

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