What is mipomersen?

Donna Hill Howes, RN
Family Practitioner

Mipomersen (Kynamro) is approved by the FDA for lowering total and LDL cholesterol in people with homozygous familial hypercholesterolemia (HoFH). HoFH is an inherited condition in which cholesterol levels are extremely high, often even with aggressive treatment with statins. Mipomersen works by limiting the production of apo-B, which is needed to build LDL cholesterol inside cells of the body. The effects of mipomersen on cardiovascular disease are not known. Mipomersen is taken once a week by injection. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

Continue Learning about High Cholesterol

Does mipomersen have any side effects?
Donna Hill Howes, RNDonna Hill Howes, RN
Side effects may include a skin reaction at the injection site, fatigue, insomnia, flu-like symptoms...
More Answers
What is the role of inflammation in high cholesterol?
Healthy HumansHealthy Humans
Today it is understood that inflammation within the arterial wall is a key factor in the progression...
More Answers
How effective are statins?
Donna Hill Howes, RNDonna Hill Howes, RN
Statins reduce the risk of cardiovascular events (heart attack, angina, or stroke), death from any c...
More Answers
Do statins interact with any other medications?
Donna Hill Howes, RNDonna Hill Howes, RN
If you are taking amiodarone, cilostazol, daptomycin, diltiazem, or imatinib, a statin may not be a ...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.