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How does Praluent (alirocumab) work to lower cholesterol?

Praluent (alirocumab) works in a way that may seem roundabout. Praluent is an antibody that targets a particular protein called PCSK9. This protein normally blocks receptors in the liver that remove LDL (bad) cholesterol from the blood. By stopping PCSK9 from working, Praluent allows those receptors to remove more LDL, which lowers people's cholesterol levels. In clinical trials prior to approval, people who took Praluent plus a statin medication lowered their LDL cholesterol by 36 to 59 percent, compared to those who took a placebo.
Keith Roach, MD
Internal Medicine
Praluent works by blocking a protein, proprotein convertase subtilisin kexin type 9. This causes the liver to take more cholesterol out of the blood, so there's less cholesterol available to contribute to blockages in the arteries, especially of the heart and brain, but in any large artery of the body.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.