Does lomitapide cause any side effects?

Donna Hill Howes, RN
Family Practitioner

Side effects may include fatigue, fever, headache, dizziness, nasal congestion, nose and throat inflammation, weight loss, back or chest pain, angina, palpitations, indigestion, acid reflux, diarrhea, nausea, vomiting, abdominal pain or bloating, constipation, flatulence, and a strong urge to defecate. Over 90% of people taking lomitapide experience gastrointestinal problems, which may be severe.

Lomitapide can raise liver enzyme levels and cause fatty liver, increasing the risk for liver disease. Lomitapide reduces the absorption of fat-soluble vitamins (A, D, E, and K). Supplements of these vitamins are recommended when taking lomitapide. Lomitapide contains lactose. People with inherited galactose intolerance or problems absorbing glucose-galactose may have diarrhea and malabsorption.

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