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What should I know before taking aldosterone blockers?

Donna Hill Howes, RN
Family Practitioner

Your doctor will need to measure your blood potassium and test your kidney function before starting treatment.

  • If you take eplerenone, you should avoid bayberry, black or blue cohosh, California poppy, cayenne, coleus, ephedra, ginger, American ginseng, golden seal, grapefruit juice, hawthorn, kola, licorice, mistletoe, periwinkle, quinine, shepherd's purse, St. John's wort, and yohimbe.
  • You should not take spironolactone or eplerenone if you are breastfeeding.
  • If you have diabetes with elevated albumin in the urine, you should not take eplerenone.
  • If you have kidney disease, an aldosterone blocker may not be a good option for you.
  • If you have liver disease, an aldosterone blocker may not be a good option for you.
  • If you are planning to become pregnant, possibly pregnant, or pregnant currently, eplerenone and spironolactone may not be good options for you. It is not known if they are safe for pregnant women. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.