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Do aldosterone blockers have any drug interactions?

Donna Hill Howes, RN
Family Practitioner

If you are taking the following drugs, the aldosterone blocker eplerenone can lead to side effects and should be avoided:

  • azole antifungal drug
  • strong CYP3A4 inhibitor
  • dabrafenib
  • fusidic acid
  • idelalisib
  • conivaptan

If you are taking the following drugs, the aldosterone blocker spironolactone can lead to side effects and should be avoided:

  • cholestyramine
  • atorvastatin

If you are taking the following drugs, the aldosterone blockers eplerenone and spironolactone can lead to side effects and should both be avoided:

  • cyclosporine
  • opioids
  • potassium supplement
  • potassium-sparing diuretic
  • tacrolimus

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.