How effective are daclatasvir and sofosbuvir?

Donna Hill Howes, RN
Family Practitioner

Daclatasvir and sofosbuvir has been reported to lower viral load within 12 weeks in over 90% of people with hepatitis C. This combination appears equally effective for people with genotype 1, 2, 3, or 4, people who also have HIV infection, and people who have not responded to telaprevir or boceprevir.

In one study, daclatasvir taken with sofosbuvir for 12 weeks lowered hepatitis C (HCV) viral load in 97% of people with both HCV and HIV infections. This study included people who had been treated for HCV before, as well as people who had not. Most of the people in the study had virus genotype 1, but treatment was about equally effective for all genotypes.

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