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What are aldosterone blockers for heart failure management?

Donna Hill Howes, RN
Family Practitioner

Aldosterone blockers often help people with systolic heart failure (reduced ejection fraction) who have symptoms despite treatment with either an ACE inhibitor or ARB, along with a beta blocker and diuretic. Aldosterone blockers available in the US include spironolactone (Aldactone) and eplerenone (Inspra).

Aldosterone blockers limit the effect of the hormone aldosterone. They help the kidneys to retain potassium, but eliminate sodium and water from the body.

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