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Which drugs can cause fatigue?

Emilia Klapp
Nutrition & Dietetics
Fatigue is a side effect of many commonly used prescription and non-prescription drugs. Some drugs cause extreme fatigue, while others cause only minor fatigue. In general, drugs that can sap your energy include:
  • Tranquilizers
  • Sleeping pills
  • Anti-hypertensives (high blood pressure medication)
  • Antidepressants
  • Antihistamines
  • Antibiotics
  • Diuretics (also called “water pills,” which stimulate the kidneys to
         produce urine)
  • Alcohol
  • Illicit drugs

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.