How are the types of gestational trophoblastic tumors related?

Dr. Jeanne Morrison, PhD
Family Practitioner

The three most common types of gestational trophoblastic tumors (GTTs) are closely related to each other. When hydatidiform mole, the most common type of GTT, spreads into the muscle of the uterus (myometrium), it is referred to as chorioadenoma destruens (invasive mole), which is the second most common type of GTT. Complete hydatidiform moles are much more likely than partial hydatidiform moles to progress to chorioadenoma destruens.

Choriocarcinomas are malignant tumors that most commonly arise from a hydatidiform mole (especially a complete type), but they can also occur after a miscarriage, therapeutic abortion, or normal pregnancy. Placental site trophoblastic tumors (PSTTs) most commonly occur after removal of a placenta during a normal pregnancy or abortion. PSTTs only occasionally arise after a hydatidiform mole has been removed.

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