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How do placental site trophoblastic tumors differ from other GTTs?

Placental site trophoblastic tumors (PSTTs) differ from the other three types of gestational trophoblastic tumors in several ways. They are less common than the other GTTs, accounting for only about 1-2 percent of all GTTs. The development of PSTTs is generally not associated with a hydatidiform mole, unlike the other types of GTT. PSTTs most commonly develop after the removal of the placenta in a regular pregnancy or an abortion, although they can sometimes develop after a hydatidiform mole has been removed.

Unlike other GTTs that are usually very susceptible to chemotherapy drugs, PSTT cells are more resistant to them. Because of this, surgery is the main treatment for this tumor, and it is performed as completely as possible, with the goal of removing all the tumor cells.

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