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How is proteomics used in ovarian cancer research?

David A. Fishman, MD
Gynecologic Oncology
Proteomics is a branch of biotechnology that evaluates the structure, interactions and function of proteins using techniques of molecular biology, biochemistry and genetics, while creating databases from the information obtained.

Tools used in proteomic analysis of ovarian cancer include mass spectrometry, enzyme-linked immunosorbent assay (ELISA) and multiplex bead arrays. Cancer is a disease that has its roots in protein pathways. This being the case, proteomics is essential to ovarian cancer research. Proteomics is used in one of two ways in cancer research. First, it may be used to determine differences in protein profiles in different states. Second, it can determine the roles of proteins in signaling pathways, their interactions and their activation states.

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