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What is the prognosis for giant axonal neuropathy (GAN)?

Diana Meeks
Diana Meeks on behalf of Sigma Nursing
Family Practitioner

Giant axonal neuropathy (GAN) generally progresses slowly as neurons degenerate and die. Most children have problems with walking in the early stages of the disorder. Later, they may lose sensation, coordination, strength, and reflexes in their arms and legs. As time goes by, the brain and spinal cord may become involved, causing a gradual decline in mental function, loss of control of body movement, and seizures. Most children become wheelchair-dependent in the second decade of life. Some children may survive into early adulthood.

This answer is based on source information from the National Institute of Neurological Disorders and Stroke.

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