What is the treatment for Adrenoleukodystrophy (ALD)?

Dr. Jeanne Morrison, PhD
Family Practitioner

All patients with ALD must undergo periodic testing for adrenal function. Treatment with adrenal hormones can be lifesaving for them. Symptomatic and supportive treatments for ALD include physical therapy, psychological support, and special education. Recent evidence suggests that a mixture of oleic acid and erucic acid, known as "Lorenzo's Oil," administered to boys with X-ALD can reduce or delay the appearance of symptoms. Bone marrow transplants can provide long-term benefit to boys who have early evidence of X-ALD. The procedure, however, carries risk of mortality and morbidity and is not recommended for patients having severe symptoms, or the adult-onset or neonatal forms. Oral administration of docosahexanoic acid (DHA) may help infants and children with neonatal ALD.

This answer is based on source information from the National Institute of Neurological Disorders and Stroke.

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