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What is neurofibromatosis type 1 (NF1)?

Neurofibromatosis type 1 (NF1) is the most common neurofibromatosis, occurring in 1 in 3,000 to 4,000 individuals in the United States. Although many affected people inherit the disorder, between 30 and 50 percent of new cases result from a spontaneous genetic mutation of unknown cause. Once this mutation has taken place, the mutant gene can be passed to succeeding generations.

This answer is based on source information from the National Institute of Neurological Disorders and Stroke.

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