Advertisement

What is lissencephaly?

Lissencephaly, which literally means "smooth brain," is a rare, gene-linked brain malformation characterized by the absence of normal convolutions (folds) in the cerebral cortex and an abnormally small head (microcephaly). It is caused during embryonic development by defective neuronal migration, the process in which nerve cells move from their place of origin to their permanent location. Symptoms of the disorder may include unusual facial appearance, difficulty swallowing, failure to thrive, muscle spasms, seizures, and severe psychomotor retardation. Hands, fingers, or toes may be deformed. Lissencephaly may be associated with other diseases, including isolated lissencephaly sequence, Miller-Dieker syndrome, and Walker-Warburg syndrome.

This Answer is based on source information from the National Institute of Neurological Disorders and Stroke .

Continue Learning about Genetic Disorders

Warning Signs of a Hereditary Angioedema Attack
Warning Signs of a Hereditary Angioedema Attack
Hereditary angioedema, also called HAE, is a rare genetic disorder that affects an estimated 6,000 to 10,000 people in the United States. People who h...
Read More
Ask the Experts: Hereditary Angioedema Treatments
Ask the Experts: Hereditary Angioedema Treatments
In this video, Darria Long Gillespie, MD, discusses the two major treatment approaches for hereditary angioedema, treatments taken to stop attacks and...
Read More
Do Hispanic people have lower rates of common cancers?
Baptist Health South FloridaBaptist Health South Florida
Hispanic people have lower rates of common cancers when compared to non-Hispanic whites. This may co...
More Answers
Can I get genetic testing for hereditary hemorrhagic telangiectasia (HHT)?
Society of Interventional RadiologySociety of Interventional Radiology
There are a few research centers in the United States that offer genetic testing for hereditary hemo...
More Answers

Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.