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What causes mitochondrial diseases?

Mitochondrial diseases can be caused by either genetic mitochondria problems or unexplained mitochondrial mutations. The types of inherited mitochondrial diseases depend on whether the affected genes are nDNA (from the nucleus) or mDNA (from the mitochondria), or a combination of both; and whether there is one (recessive) or two (dominant) copies of the gene.
Non-inherited mitochondrial diseases arise from unexplained mutations, with exposure to certain harmful substances or environmental factors occasionally found to be the cause.

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