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What issues can acid sphingomyelinase deficiency (ASMD) cause in the spleen?

In acid sphingomyelinase deficiency (ASMD), sphingomyelin buildup causes cells in the spleen to swell. The spleen has some important jobs to do. Normally, it helps to fight off infections, and it gets rid of cells that don’t work properly. But in chronic ASMD, the swollen cells mean that the spleen gets bigger and bigger. It can also cause the tummy to stick out. When the spleen is swollen it is easily damaged and may bleed if it is knocked.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.