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What causes gallbladder cancer?

Gallbladder cancer is caused by changes in the DNA of the cells that line the gallbladder, causing abnormal growth. While your DNA is inherited from your mother and father, changes may occur spontaneously, or as a response to certain substances. In the case of gallbladder cancer, scientists believe that chronic inflammation may lead to some detrimental DNA changes. The p53 tumor suppressor gene is often implicated in this form of cancer. A tumor suppressor gene works by blocking the abnormal growth of cells, and when it is de-activated, as in the case of gallbladder cancer, overgrowth can occur. FHIT, k-ras, b-RAF, CDKN2, and HER2 are other genes that have been implicated in gallbladder cancer.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.