Is appendix cancer an orphan disease?

Diana Meeks on behalf of Sigma Nursing

Family Practitioner

An orphan disease is a rare disease that affects a small number of people in comparison to other more common diseases. Appendix cancer is an orphan disease, affecting 600-1000 Americans a year. Appendix cancer and other orphan disease do not affect enough people to attract pharmaceutical and medical researchers in pursuit of profit. Treatments for appendix cancer have not undergone clinical trials because it is so rare.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.

Gastrointestinal Cancer

Caused by tumors that grow slowly in our digestive system, gastrointestinal cancers can affect the appendix, stomach, small intestine, colon and rectum. With no known cause, the tumors that cause these cancers usually do not show symptoms until after they have spread. See your doctor if you have shortness of breath, abdominal discomfort or bloating, rectal bleeding or bowel obstruction. You are at greater risk for developing gastrointestinal cancers if you have a family history of the cancers, are older than 50 or have other gastric problems, such as gastritis. Tumors called carcinoids and non-carcinoids cause cancer in the gastrointestinal tract, which houses the stomach and the intestines. Most carcinoid tumors are found in the tip of the appendix, which is attached to the large intestines. Tumors are often found when a person is treated for appendicitis or a doctor notices it accidentally in a CT scan. Aggressive treatments, such as surgery, are needed for large tumors.

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