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What should I know when using glycopyrrolate?

Glycopyrrolate (Robinul) is a prescription drug given with other medications to treat peptic ulcers, sores in the lining of the stomach (gastric ulcers) or the first part of the small intestine in an area called the duodenum (duodenal ulcers). Glycopyrrolate belongs to a class of drugs called anticholinergic medications. It helps to treat ulcers by decreasing the amount of acid made in the stomach.

Glycopyrrolate tablets come in 1 milligram (mg) and 2 mg strengths. Depending on which dose you take, your doctor will probably tell you to take the pills two or three times a day at equally spaced intervals. The maximum recommended dosage of glycopyrrolate is 8 mg per day.

People who have certain medical conditions may not be good candidates for glycopyrrolate, including those who:
  • have had an allergic reaction to glycopyrrolate or any of its ingredients in the past
  • are pregnant, breastfeeding or plan to become pregnant soon (women)
  • have trouble urinating
  • have glaucoma
  • have the autoimmune disease myasthenia gravis
  • have ulcerative colitis
  • have a blockage in your gastrointestinal tract
  • exercise vigorously in hot weather, or work in hot conditions. Glycopyrrolate may interfere with sweating, raising the risk of becoming overheated.
  • have a hiatal hernia with reflux
  • have problems with your kidney, liver, heart, bowel or thyroid
  • have high blood pressure
  • have an enlarged prostate gland (men)
  • have a nervous system disorder
Glycopyrrolate can cause side effects, including drowsiness and blurred vision, so don't plan to drive or operate machinery until you see how the drug affects you, and be aware of these other potential side effects:
  • signs of allergic reaction including itching or hives, chest tightness, trouble breathing, or swelling in your hands, face, mouth or throat
  • diarrhea or constipation
  • racing or pounding heartbeat
  • lightheadedness or fainting
  • muscle weakness or stiffness
  • any other symptom that is severe or persistent

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.