What should I know before taking sulfasalazine?

Donna Hill Howes, RN
Family Practitioner

Your doctor will need to do blood tests and check your liver function before you start treatment.

If you have asthma, recurrent infections, impaired kidney function, or impaired liver function, sulfasalazine may not be a good option for you.

Sulfasalazine is not recommended for people with psoriatic arthritis affecting the spine or sacroiliac joints.

Some people with agranulocytosis, aplastic anemia, and other blood diseases have had fatal reactions to sulfasalazine.

If you have glucose-6-phosphate dehydrogenase deficiency, sulfasalazine may cause hemolytic anemia.

If you have intestinal obstruction, porphyria, or urinary tract obstruction, you should not take sulfasalazine.

Sulfasalazine may not be a good option for pregnant women, women who may be pregnant, or women who are planning pregnancy. It is not known if it is safe for pregnant women.

Sulfasalazine is passed into breast milk and may not be a good option for breastfeeding women.

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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