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Do proton pump inhibitors have any side effects?

Donna Hill Howes, RN
Family Practitioner

Side effects may include headaches, abdominal pain, nausea, vomiting, diarrhea, and constipation.

PPIs suppress acid production in the stomach. Long-term use may interfere with absorbing calcium, iron, magnesium, and vitamin B12. Reduced calcium absorption can lead to a decrease in bone density. The relationship between PPI use and the risk for fractures is not clear. 

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Dr. Kent A. Holtorf, MD
Endocrinologist

Proton pump inhibitors, such as Nexium, Protonics and Prevacid, are associated with dramatic increase in bacterial overgrowth of the gut causing irritable bowel syndrome and significant risk of acquiring diarrhea causing infections of the bowel. They are also shown to reduce the absorption of thyroid hormone replacement and to increase the risk of osteoporosis and fractures.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.