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Do proton pump inhibitors interact with other medications?

Donna Hill Howes, RN
Family Practitioner

If you are taking any of these medications, proton pump inhibitors can lead to side effects and should be avoided:

  • cefditoren
  • dabrafenib
  • delavirdine
  • nelfinavir
  • pimozide
  • posaconazole
  • rifampin
  • rilpivirine
  • risedronate
  • a tyrosine kinase inhibitor

If you are taking bosentan, omeprazole can lead to side effects and should be avoided.

If you are taking escitalopram, omeprazole may not be a good option for you.

If you are taking clopidogrel, esomeprazole can lead to side effects and should be avoided.

If you take a proton pump inhibitor, you should avoid St. John's wort. 

This answer was adapted from Sharecare's award-winning AskMD app. Start a consultation now to find out what's causing your symptoms, learn how to manage a condition, or find a doctor.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.