Do promethazine suppositories interact with other drugs?

Some medications might react poorly with promethazine suppositories and should be avoided or used with caution when combined. Problem medicines may include the following:

  • muscle relaxers
  • painkillers
  • MAO inhibitors
  • epinephrine (adrenaline)
  • blood thinners
  • drugs that make you sleepy (sleeping pills, sedatives, etc.)
  • medicines that treat high blood pressure
  • Parkinson's disease
  • depression
  • anxiety
  • ulcers
  • motion sickness
  • irritable bowel disease
  • urinary disorders
  • restless leg syndrome
  • pituitary gland tumors
  • spasms
  • mental illness

Other medications that treat cold and allergy symptoms should also be avoided. You should tell your doctor about all medicines, supplements, vitamins and herbal remedies that you take before starting on promethazine suppositories. Also, avoid drinking alcohol while taking promethazine, as it can worsen some of the drug's side effects.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.