How is mesalamine given?

Mesalamine (Asacol HD, Canasa, Pentasa, Rowasa, 5-ASA) is an anti-inflammatory drug used to reduce disease activity, pain and swelling caused by the erosion of the lining of the lower colon and rectum from ulcerative colitis and proctitis. It comes in pill form, as a suppository and as an enema inserted into the rectum. The suppository should be moistened with water prior to insertion. If suppository is too soft because of storage in a warm place, chill in the refrigerator for 30 minutes or run cold water over it before removing the wrapper. The suppository should be retained in rectum for at least one to three hours to ensure maximum benefit. The enema should be shaken well prior to administering and should be administered at bedtime. It is best to retain enema for at least eight hours.

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