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How does promethazine treat nausea?

Promethazine blocks acetylcholine receptors to control nausea and prevent vomiting. Children under two years old should not be treated with promethazine. The medication does not treat the underlying cause of nausea and vomiting, but rather controls the symptoms. Promethazine is not intended to control nausea and vomiting in children except in cases of prolonged vomiting when the cause of the vomiting is known and clear. In cases of severe vomiting, using promethazine suppositories rectally will avoid further agitation to the stomach and decreased effectiveness of the medication. If in a hospital setting, promethazine may be administered intravenously for the same purpose.

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