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How can proton pump inhibitors (PPIs) cause bone loss?

Dr. Michael Roizen, MD
Internal Medicine
The proton pump inhibitor (PPI) you've been using for acid reflux may contribute to bone loss. There's evidence that PPIs weaken bones, partly by interfering with calcium absorption. Usually, this only increases fracture risk at high doses or over a long period of time.

Talk with your doc about swapping your PPI for an H2 antagonist ( “H” is for histamine) such as Zantac, Pepcid or Tagamet. There's evidence that H2 antagonists are not associated with fractures and may even protect bones.

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