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What are the risks in taking promethazine?

Promethazine increases the risk of seizure, therefore, individuals who have a history of seizures or epilepsy should discuss the condition with their doctors. The medication worsens other conditions, such as Alzheimer's, glaucoma and enlarged prostate. Because promethazine causes central nervous system depression, the medication should not be used with alcohol, narcotics, anti-depressants or certain other types of medications. The sedative effect of promethazine tablets and suppositories may impair performance of potentially dangerous tasks and driving.

Precautions should be taken when administering promethazine to children. Because they are at increased risk for potentially fatal respiratory depression, children under two years of age should not use promethazine.

If used intravenously, promethazine may potentially cause tissue damage, possibly leading to gangrene. For this reason, the medication should never be injected directly under the skin or administered by IV push, but instead should be injected into the muscle or administered as an IV drip. Give your doctor a complete history of medical conditions you have or have had so that your doctor can determine if promethazine may adversely affect you.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.