What should I know about salsalate before taking it?

The most severe side effects from salsalate involve the circulatory system, and taking this drug may increase your risk of heart attack, stroke or other bleeding disorders. Before using the drug, you should talk to your doctor about your medical history, particularly if you have heart disease, high blood pressure, a bleeding disorder, anemia, diabetes, intestinal bleeding or dehydration. Nasal polyps, asthma and enzyme deficiency may also affect this medication. If you are allergic to aspirin or any other non-steroidal anti-inflammatory drug, you should not take salsalate. You should be careful about using other medications that might interact with salsalate, including angiotensin-converting enzyme inhibitors (ACEIs) like captopril, antacids, diuretics, gout medications, diabetes medications, selective serotonin reuptake inhibitors (SSRIs), blood clot medication, sodium bicarbonate, seizure medication, blood thinners, steroids, acetazolamide, cyclosporine, lithium, methotrexate, pemetrexed and tenofovir. Be aware that while taking salsalate, smoking and drinking may increase the risk of stomach bleeding and amplify impaired judgment.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.