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What should I know about promethazine suppositories?

There are certain precautions you should be aware of before using promethazine suppositories. They may cause harmful reactions if you have a history of certain medical conditions, including: cancer, high blood pressure, glaucoma, seizures, diabetes, liver, heart or kidney disease, difficulty with breathing or urination, stomach problems, an overactive thyroid or a bone marrow disorder. Similarly, promethazine may interact poorly with certain medications, such as: muscle relaxers, painkillers, MAO inhibitors, epinephrine (adrenaline), blood thinners and drugs that make you sleepy (sleeping pills, sedatives, etc.). It may also interact badly with medicines that treat high blood pressure, Parkinson's disease, depression, anxiety, ulcers, motion sickness, irritable bowel disease, urinary disorders, restless leg syndrome, pituitary gland tumors, spasms or mental illness. In addition, avoid medications that treat cold and allergy symptoms.

If you are pregnant or breastfeeding you should alert your doctor, as promethazine may cause damage to the developing fetus or nursing child's health. Also be aware that promethazine suppositories may cause serious side effects, ranging from fatigue and lightheadedness to seizures and hallucinations. If you experience any of these serious side effects, seek medical attention immediately. Additionally, you should not drink alcohol while taking the medication. Certain laboratory tests may be affected by promethazine, so let your doctor or lab technician know you are taking it. Finally, you should know that promethazine suppositories are for rectal use only and should be refrigerated.

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Important: This content reflects information from various individuals and organizations and may offer alternative or opposing points of view. It should not be used for medical advice, diagnosis or treatment. As always, you should consult with your healthcare provider about your specific health needs.