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How does the Roux-en-Y procedure work against diabetes?

Gastric bypass surgery has been shown to improve or resolve type 2 diabetes mellitus in a large proportion of patients. The exact cause of this outcome is still under investigation, but has been attributed to a number of factors. Initially, the improvement of diabetes with gastric bypass surgery was thought to be secondary to the associated weight loss that is achieved. However, many patients saw improvements far earlier than that which could be explained by weight loss alone. In fact, patients were able to leave the hospital after surgery on a much lower medication regimen than their pre-operative regimen. Research in this field has shown that the gut hormones of patients who undergo bariatric surgery is changed compared to those who do not. Although the exact mechanism for this improvement has yet to be identified, we believe that the change in the hormonal milieu is at least in part the reason for this outcome. This remains to be an exciting field within surgery with much ongoing research.

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